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- Newsgroups: alt.drugs
- From: lamont@hyperreal.com (Lamont Granquist)
- Subject: Medline info on drug-drug interactions
- Message-ID: <1993Oct25.205133.10949@beaver.cs.washington.edu>
- Date: Mon, 25 Oct 93 20:51:33 GMT
-
- ----------------------------------------------------------------------
- On drug-drug interactions:
-
- Accession Number: 93000357. Citation: 2 of 4
-
- Author: Strassman-R-J.
- Title: Human hallucinogen interactions with drugs affecting
- serotonergic neurotransmission.
- Source: Neuropsychopharmacology. 1992 Nov. 7(3). P 241-3.
- Abstract: The absence of relevant human research studies of
- hallucinogenic drugs has not curtailed their unsupervised
- use. Two cases are presented that suggest decreased
- sensitivity to the serotonergic hallucinogens psilocybin and
- LSD induced by drugs with effects on serotonergic
- neurotransmission, allopurinol and fluoxetine. These reports
- suggest that hallucinogens' effects in humans are mediated by
- serotonergic receptors.
-
- Accession Number: 92272338. Citation: 3 of 4
-
- Author: Picker-W. Lerman-A. Hajal-F.
- Title: Potential interaction of LSD and fluoxetine [letter]
- Source: Am-J-Psychiatry. 1992 Jun. 149(6). P 843-4.
-
- Accession Number: 93359556. Citation: 1 of 45
-
- Author: McCann-U-D. Ricaurte-G-A.
- Title: Reinforcing subjective effects of (+/-)
- 3,4-methylenedioxymethamphetamine ("ecstasy") may be
- separable from its neurotoxic actions: clinical evidence.
- Source: J-Clin-Psychopharmacol. 1993 Jun. 13(3). P 214-7.
- Abstract: (+/-)3,4-Methylenedioxymethamphetamine (MDMA), a synthetic
- amphetamine derivative used recreationally by humans, damages
- brain serotonin neurons in experimental animals. In
- preclinical studies, serotonin reuptake inhibitors block
- MDMA-induced serotonin release; they also block MDMA
- neurotoxicity. Whether serotonin reuptake inhibitors also
- block MDMA's psychoactive effects in humans has not been
- established. Reported herein are four individuals who
- describe their experiences after ingesting fluoxetine, a
- potent and selective serotonin reuptake inhibitor, before
- MDMA ingestion. Their reports indicate that fluoxetine does
- not block MDMA's reinforcing subjective effects and raise the
- possibility that MDMA's psychoactive effects may be separable
- from its neurotoxic actions.
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